Author Archives: David Melamed, PhD

HAE International, a global nonprofit that supports local hereditary angioedema (HAE) patient groups and organizations, has expanded their emergency card template to a total of 34 languages — and plans to add more in the future. The emergency cards are a means for patients to quickly and…

The U.S. Patent and Trademark Office (USPTO) issued a new allowance for a patent submitted by BioCryst Pharmaceuticals for berotralstat (BCX7353), an investigational therapy to treat hereditary angioedema (HAE). The USPTO issued a notice of allowance to BioCryst, indicating future approval. Once approved, the new…

The Committee for Medicinal Products for Human Use (CHMP), part of the European Medicines Agency (EMA), is recommending the approval of a prefilled syringe to administer Takhzyro (lanadelumab), a preventative treatment for hereditary angioedema (HAE) in patients 12 or older. The European Commission (EC), which typically accepts…

People with hereditary angioedema (HAE) caused by a specific mutation in the plasminogen gene have several on-demand and preventive treatment options that reduce the severity and frequency of their acute swelling attacks, a study has found. The study, “Treatment of Hereditary Angioedema with the Mutation…

A new diagnostic tool has been identified for people with hereditary angiodema (HAE) and normal C1 inhibitor activity, potentially establishing the first method that doctors can use to properly diagnose this genetic condition, a study suggests. The study, “sgp120 and the contact system in hereditary…

Use of ACE inhibitors to treat high blood pressure can sometimes cause swelling (angioedema) episodes, but the prevalence of this potentially life-threatening side effect is not well-known because it is rarely reported, a Danish study into a “drug reaction” database found. The study, “ACE-Inhibitor Related Angioedema Is…

Researchers have identified risk factors that may predispose children to more severe initial angioedema attacks — factors such as male gender, preschool age, presence of fever or hives, and a history of allergies. Epinephrine treatment and receiving care in a pediatric observation unit, on the other hand, were factors that…