A single dose of PHA121 (PHA-022121), Pharvaris’ investigational therapy for hereditary angioedema (HAE), is safe and can rapidly and sustainably block bradykinin-induced changes in blood parameters, according to two studies in healthy volunteers. According to the company, these findings indicate PHA121 may be well…
Routine injectable treatments to prevent hereditary angioedema (HAE) attacks place a large burden on patients and their caregivers, a survey study has found. Surveyed patients and doctors also agreed that less burdensome and easier-to-administer preventive treatments are needed to improve the quality of life and independence of those with…
The U.S. Food and Drug Administration (FDA) has extended the use of Haegarda, a C1-INH replacement medication, as a routine treatment to prevent hereditary angioedema (HAE) attacks in children ages 6 and older. Haegarda, a prophylactic treatment available as an under-the-skin (subcutaneous) injection that can be taken at…
The lack of control of a key enzyme associated with the overproduction of bradykinin seems to be the common root cause of all forms of hereditary angioedema with normal C1-inhibitor activity, a study reports. The study, “Impaired control of the contact system in hereditary angioedema with…
Angioedema News brought you daily coverage of important discoveries, treatment developments, clinical trials, and other important events dealing with angioedema throughout 2019. As a reminder of what mattered most to our readers in 2019, here are the 10 most-read articles of last year, with a brief description of…
KVD001 safely protects people with diabetic macular edema from losing their vision, according to a Phase 2 trial conducted by the treatment’s developer, KalVista Pharmaceuticals. DME is a form of angioedema that is caused by the leaking of blood vessels which lead to fluid accumulating in the…
The Canadian Drug Expert Committee (CDEC) has recommended that Takhzyro (lanadelumb) be reimbursed by public drug plans when used as a preventive treatment for hereditary angioedema (HAE) attacks in patients 12 and older. “HAE is a chronic disease that results in acute attacks of swelling…
The National Institute for Health and Clinical Excellence (NICE) has recommended Takhzyro (lanadelumb) as a preventive treatment for hereditary angioedema (HAE) attacks in patients 12 and older, under certain conditions. NICE’s final appraisal determination (FAD) states that Takhzyro should be used only if: patients…
Prophylactic, or preventive treatment with Haegarda quickly reduced the number of attacks — sudden episodes of swelling — in people with hereditary angioedema (HAE) caused by C1-inhibitor deficiency, an exploratory analysis of a Phase 3 trial shows. The number of attacks were reduced regardless of baseline patient characteristics.
A single dose of Ruconest (conestat alfa) was sufficient to rapidly and safely treat almost 96% of all acute attacks in a group of children with hereditary angioedema (HAE), Phase 2 trial data show. The treatment was approved for acute HAE attacks in adults and adolescents by the…
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