A 26-year-old woman developed a rare case of non-episodic angioedema associated with eosinophilia (NEAE) following her second dose of the Pfizer-BioNTech COVID-19 vaccine, according to a study from Japan. Eosinophilia refers to higher-than-normal levels of a type of immune cells called eosinophils. Her NEAE symptoms were resolved completely two months…
The use of Dupixent (dupilumab), an approved treatment for skin and respiratory conditions linked to a specific type of inflammation, led to the development of angioedema in a woman in her 40s, as described in a new case report from U.S. researchers. The woman, who had a type…
People with hereditary angioedema (HAE) are able to recognize early signs of swelling attacks and the need to get prompt on-demand treatment to manage them, new research highlights. Findings were presented by KalVista Pharmaceuticals in a series of posters at the recent U.S. Hereditary Angioedema Association (HAEA)…
The U.S. Food and Drug Administration (FDA) has given STAR-0215 fast track status to help speed up its development and make it available to patients sooner. An experimental medication to prevent swelling attacks in hereditary angioedema (HAE), with dosing once every three or six months, STAR-0215 is in…
BioCryst Pharmaceuticals is teaming up with Er-Kim Pharmaceuticals to commercialize Orladeyo (berotralstat) in Turkey. Orladeyo is an oral therapy, taken once a day, to prevent swelling attacks with hereditary angioedema (HAE). Er-Kim, based in Istanbul, partners with pharma companies to bring new therapies to markets around…
Pediatricians in Brazil show, in general, a low level of knowledge of hereditary angioedema (HAE), according to a recent study. Even though those who were board-certified specialists in allergy and immunology were more knowledgeable than those who weren’t, their level of knowledge was still considered unsatisfactory. “Based on the…
Healthcare costs continuously dropped for people with hereditary angioedema (HAE) who were on long-term preventive treatment with Takhzyro (lanadelumab), according to a retrospective analysis of healthcare insurance claims from a U.S. database. Findings were reported in a study, “Real-world changes in costs over time among…
The Phase 3 clinical trial of oral sebetralstat as an on-demand treatment for swelling attacks in people with hereditary angioedema (HAE) has reached its target enrollment of 114 patients. Findings from the global KONFIDENT study (NCT05259917) are expected by year’s end, according to the therapy’s developer,…
Firazyr (icatibant injection) rapidly eased acute attack symptoms in two Japanese children with hereditary angioedema (HAE), according to a study led by Takeda Pharmaceuticals, its developer. The therapy’s safety and pharmacological profile was also consistent with previous observations of adults and other pediatric patients. Firazyr’s approval in…
A woman still doesn’t have a definitive answer as to the underlying cause of her angioedema after more than a decade of recurrent facial swelling, underscoring the difficulties in diagnosing the condition. “This case report demonstrates the challenge of the differential diagnosis of angioedema without wheals,” the researchers wrote…
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