Author Archives: Alice Melao

Phase 1 Trial in Healthy Volunteers Supports Continued Development of ATN-249 for HAE

Attune Pharmaceuticals‘ ATN-249, an investigational kallikrein inhibitor for the prevention of swelling attacks in hereditary angioedema (HAE) patients, was found generally safe and well-tolerated in a Phase 1 clinical trial with healthy volunteers, the company announced. Findings from this first-in-human trial (ACTRN12618000430235) were also presented during the recent …

Rare Case of Angioedema Linked to Crestor, a Statin, Reported in Case Study

Medications that lower cholesterol levels, collectively known as statins, can in rare instances trigger angioedema episodes that are self-resolving if the patients stops using the statin, a case study reports. The study describes a side effect of Crestor (rosuvastatin), but its researchers caution that other, chemically-related statins could also…

FDA Gives Fast Track to BCX7353 for Preventing Attacks in HAE Patients

The U.S. Food and Drug Administration (FDA) has granted fast track status to BCX7353, an investigational therapy being developed by BioCryst Pharmaceuticals, for the prevention of angioedema attacks in patients with hereditary angioedema. That status will support the development of BCX7353, speed its review and, depending on how it…