Posts by: Alice Melao

News

Regenxbio is exploring a new hereditary angioedema (HAE) treatment that harnesses viral vectors to deliver an antibody-based gene therapy, the company announced. The treatment will deliver the genetic sequence ... Read more

January 31, 2019

Phase 1 Trial in Healthy Volunteers Supports Continued Development of ATN-249 for HAE

News

Attune Pharmaceuticals‘ ATN-249, an investigational kallikrein inhibitor for the prevention of swelling attacks in hereditary angioedema (HAE) patients, was found generally safe and well-tolerated in a Phase 1 clinical ... Read more

November 15, 2018

Phase 2 Trial Planned for Investigational HAE Therapy KVD900 After Positive Phase 1 Results

News

KalVista Pharmaceuticals’ investigational candidate KVD900, being developed for the treatment of hereditary angioedema (HAE), is safe and effectively inhibits kallikrein, the main driver of HAE attacks, results from a ... Read more

October 16, 2018

Patients with Angioedema Have Worse Response to Urticaria Treatment Xolair

News

Angioedema seems to predict poorer responses and lower chances of remission in chronic urticaria patients receiving Xolair (omalizumab), a retrospective study shows. The study, “Angioedema is an unfavorable factor for ... Read more

September 25, 2018

FDA Rejects Ruconest Label Expansion for HAE Swelling Prevention, Citing Need for More Clinical Data

News

The U.S. Food and Drug Administration has rejected Pharming’s request to expand the label of Ruconest (conestat alfa) to include routine prevention of swelling attacks caused by hereditary angioedema ... Read more

September 20, 2018

Rare Case of Angioedema Linked to Crestor, a Statin, Reported in Case Study

News

Medications that lower cholesterol levels, collectively known as statins, can in rare instances trigger angioedema episodes that are self-resolving if the patients stops using the statin, a case study ... Read more

August 9, 2018

FDA Gives Fast Track to BCX7353 for Preventing Attacks in HAE Patients

News

The U.S. Food and Drug Administration (FDA) has granted fast track status to BCX7353, an investigational therapy being developed by BioCryst Pharmaceuticals, for the prevention of angioedema attacks in ... Read more

July 3, 2018July 3, 2018

In Rare Cases, Stroke Treatment Can Trigger Life-threatening Angioedema, Case Report Shows

News

Activase (alteplase), a common treatment for stroke, may trigger angioedema of the mouth and tongue that can lead to a life-threatening situation if not treated promptly, a case report ... Read more

May 31, 2018

Heart Medication Entresto Does Not Increase Angioedema Risk Compared with Standard Therapy, Study Finds

News

Entresto (sacubitril/valsartan) — an approved medication for heart failure — does not significantly increase the risk of angioedema compared with standard therapy Vasotec (enalapril), data from a Phase 3 trial ... Read more

May 24, 2018May 24, 2018

Human Plasma-derived C1-INH Can Help Manage Hereditary Angioedema During Pregnancy, Study Reports

News

Treatment with human plasma-derived C1-INH is an effective and safe option for managing symptoms of severe hereditary angioedema during pregnancy and delivery, a Swedish case report suggests. The study, ... Read more