Ana Pena, PhD,  —

BioCryst Pharmaceuticals presented new results from a Phase 3 clinical trial showing that preventive treatment with oral berotralstat (BCX7353) significantly lowers the frequency and may also lessen the severity of swelling attacks in people with hereditary angioedema (HAE). The findings would have been shared at the…

Ruconest (rhC1INH) is safe and effective as an on-demand therapy to treat acute swelling attacks, and as a short-term prophylaxis to prevent attacks of hereditary angioedema (HAE), a study in Hungary found. Early administration of Ruconest speeds the full resolution of an attack, and repeated use does not…

Intellia Therapeutics announced the first preclinical results supporting a gene therapy candidate for hereditary angioedema (HAE). In animal models, the product markedly and sustainably lowers kallikrein activity to levels of expected therapeutic benefit, anticipated to lessen angioedema attacks in patients. The early data comes on the…

BioCryst Pharmaceuticals has submitted a new drug application (NDA) to the U.S. Food and Drug Administration (FDA) requesting the approval of  berotralstat (BCX7353), a once daily, oral treatment to prevent swelling attacks in people with hereditary angioedema (HAE). The latest results of APeX-S and APeX-2…

Factors involved in blood vessel permeability — called VEGF-A, VEGF-C, and sPLA2 — may predispose people who take ACE inhibitor medications for high blood pressure to develop non-allergic angioedema, a study reports. Moreover, the findings indicate that switching to sartans, another class of antihypertensive medicines,…

BioCryst Pharmaceuticals has licensed rights to Torii Pharmaceutical for the commercialization of BCX7353 — an oral, once-daily investigational therapy for the prevention of hereditary angioedema (HAE) attacks — in Japan, pending the treatment’s approval. The plan is for BioCryst to submit a Japanese new drug application (JNDA)…

Short-term use of Ruconest (recombinant human C1 inhibitor) as a preventive treatment reduces the risk of hereditary angioedema (HAE) attacks triggered by medical and dental procedures or by stress, a case series reports. The study, “Recombinant Human C1 Esterase Inhibitor as Short-Term Prophylaxis…

Firazyr (icatibant acetate) does not appear to be superior to placebo or symptomatic therapies in treating attacks of angioedema (swelling) caused by angiotensin-converting enzyme (ACE) inhibitors, a pooled analysis of three clinical studies shows. In all trials combined, injections of Firazyr considerably shortened mean time to…

The case of a man with hereditary angioedema (HAE) who remained undiagnosed for 62 years underscores the importance of carefully evaluating not only the clinical data of suspected patients, but also their family history. Due to the diagnosis delay the patient…

Asphyxiation caused by head and neck angioedema — swelling and fluid accumulation in the deeper layers of the skin — is rare, and most such deaths are due to bradykinin-mediated disease, a French study reported. In fact, bradykinin-mediated disease is 45 times more likely to be…