Margarida Maia, PhD,  science writer—

Three genetic regions were found to be associated with the risk of developing angioedema as a side effect of angiotensin-converting enzyme (ACE) inhibitors, according to a genome-wide association study (GWAS) of European and African-American people. These include a new genetic locus that hadn’t been…

People with hereditary angioedema (HAE) who switched from long-term androgen treatment to BioCryst Pharmaceuticals’ Orladeyo (berotralstat) saw a reduction in the number of swelling attacks. That’s according to a new analysis of data from patients who discontinued androgens less than 60 days (two months) before entering APeX-S…

Argentina’s regulatory body has approved BioCryst Pharmaceuticals’ Orladeyo (berotralstat) to prevent swelling attacks in adults and adolescents, ages 12 and older, who have hereditary angioedema (HAE). The decision by the National Administration of Drugs, Foods, and Medical Devices (ANMAT) comes a few months after the approval of…

Donidalorsen, an experimental treatment in the pipeline of Ionis Pharmaceuticals, continues to prevent swelling attacks when taken for up to two years, allowing a better quality of life for adults with hereditary angioedema (HAE). These results come from an ongoing open-label extension study (NCT04307381) in HAE…

Pharvaris is now gearing up startup activities with clinical site investigators and staff to launch a Phase 3 trial next year of PHVS416 — an immediate-release capsule formulation of deucrictibant — as an on-demand treatment for hereditary angioedema (HAE). The Switzerland-based clinical-stage company recently met with the U.S. Food…

A 58-year-old woman developed angioedema of the small bowel after three years of taking lisinopril, an angiotensin-converting enzyme (ACE) inhibitor often used for high blood pressure. The woman switched to amlodipine, a different blood pressure-lowering medication, and her signs and symptoms of angioedema resolved rapidly. Her case was…

Children with hereditary angioedema (HAE) may have dozens of swelling attacks until they receive a correct diagnosis of the disease, according to a study in a hospital in Turkey, where the median delay was three years. “Awareness of the symptoms of HAE is necessary and correct diagnosis is…

A 3-point score increase is the minimum change on the widely used Angioedema Control Test (AECT) to reflect meaningful improvement in disease control for people with recurrent angioedema, a study showed. The AECT was developed to help patients keep score of disease control over a recall period, but…

On-demand and preventive treatment with either icatibant injection or C1 inhibitor (C1-INH) concentrates — which are approved for hereditary angioedema (HAE) — also can help people with acquired angioedema keep swelling under control, according to a small study in Germany. People severely affected with acquired angioedema and no “underlying condition…

People who develop angioedema due to common high blood pressure medications known as angiotensin-converting enzyme (ACE) inhibitors may be at an increased risk of a cardiovascular event in the few months after discontinuing treatment, a study has found. While it’s not clear if switching to an alternative treatment may…