Marisa Wexler, MS,  senior science writer—

A genetic technique called allelic discrimination — which detects a specific variant of the F12 gene — might make diagnosing certain hereditary angioedema-causing mutations quicker and cheaper, a new study showed. Titled “A cost-effective algorithm for diagnosis of hereditary angioedema with normal C1 inhibitor:…

Researchers have developed a new rat model of hereditary angioedema (HAE) that more closely mimics the swelling episodes experienced by humans, which might improve studies about the mechanisms that cause the disease. The model has been described in a new paper, “Endothelial B2-receptor overexpression as an…

In a new study, researchers provide recommendations for when to consider a diagnosis of hereditary angioedema (HAE) for patients who come to the  emergency room with swelling. The study, “Development of the Hereditary Angioedema Rapid Triage (HAE-RT) Tool,” was published in The Journal of Allergy…

Haegarda, a concentrated form of C1 inhibitor (C1-INH), is safe and effectively helps to prevent hereditary angioedema attacks in the long-term, allowing patients to become free of disease symptoms, That is the finding of a Phase 3 extension study, “Long-term outcomes with subcutaneous C1-inhibitor replacement therapy for prevention…

Some mutations in the SERPING1 gene that cause hereditary angioedema (HAE) result in an abnormal form of the C1 inhibitor (C1-INH) that binds to and traps healthy C1-INH in cells, severely reducing the amount of protein available to prevent HAE attacks, a study shows. The study, “Dominant negative SERPING1…

Physicians in Canada need better education about the multiple biological assays used to diagnose hereditary angioedema caused by C1 inhibitor deficiency (C1-INH-HAE), which will increase their confidence and access to relevant tests, a study shows. The study, “The diagnosis of hereditary angioedema with C1 inhibitor deficiency: a survey…