Researchers for the first time have developed separate liver cell lines, each derived from people with hereditary angioedema (HAE), that accurately replicate the molecular and cellular processes underlying the condition. “These models not only exhibit key molecular features of HAE but also provide a versatile platform for mechanistic studies…
Note: This story was updated May 26, 2026, to correct the time until symptom relief and the two formulations being investigated. Deucrictibant began relieving symptoms within a median of 1.28 hours. Developer Pharvaris is testing both immediate-release capsules and extended-release tablets. Pharvaris plans to soon submit an application to…
Discussion
When my family first moved to Colorado almost 20 years ago, I was surprised to see snow in early October, and even on Mother’s Day in the spring. It was especially odd considering we don’t live in the mountains, and the summers here are so warm. But this year, we…
People with hereditary angioedema (HAE) who learn to accept and manage their disease, rather than constantly fighting or fearing it, often experience better mental well-being and a fuller, more active life, according to a survey study from the U.K. “Approaches aimed at fostering acceptance may offer a valuable means…
Angioedema is the formal medical term for swelling under the skin. It usually occurs as part of an allergic reaction, but has forms that are not due to allergies.
Acute angioedema often occurs as part of an allergic reaction to various allergens or triggers. These can include certain foods, insect bites or stings, medications, and natural rubber products like latex.
Angioedema and hives often occur at the same time. However, angioedema causes large, thick welts which may not be itchy, whereas hives are smaller and usually itchy.
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