Andrea Lobo,  —

The case of a man with a rare form of hereditary angioedema (HAE) where the levels of the C1-inhibitor (C1-INH) protein were normal, referred to as HAE-nl-C1INH, was described by researchers in Japan. While this form of HAE is most commonly seen in women and is usually associated with…

Most people with hereditary angioedema (HAE) can usually predict an impending swelling attack based on early, or prodromal, signs or symptoms, according to an online survey. However, results showed differing behaviors and definitions for “early treatment,” with 60% of the participants taking medications as soon as early symptoms…

An 83-year-old woman suddenly developed angioedema of the airway as a result of neck trauma while being treated with telmisartan, a medication commonly used to lower blood pressure, according to a case report from the U.S. “This case report highlights the rare and often forgotten adverse reaction of angioedema…

Mutations in the CPN1 gene leading to a deficiency in the activity of the carboxypeptidase N (CPN) enzyme were found in four families with hereditary angioedema (HAE),  according to a new study from Europe. The team of researchers identified three genetic variants in the CPN1 gene that were associated…

A 60-year-old man with hereditary angioedema (HAE) caused by an unknown mutation developed visual loss due to swelling of the optic nerve in both eyes, according to a case reported in Italy. His symptoms eased after starting treatment with Berinert (human C1 esterase inhibitor), an intravenous (into-the-vein) C1…

Long-term preventive treatment with Haegarda reduced the number and severity of attacks and the use of rescue medications in people with hereditary angioedema (HAE), while improving their quality of life, a recent study has found. “These real-world findings indicate that long-term prophylaxis with [Haegarda] markedly improves important factors that…

Long-term prophylaxis, or preventive treatment, with Orladeyo (berotralstat) is well tolerated, and results in sustained reductions in swelling attacks and gains in quality of life in adolescents and adults with hereditary angioedema (HAE). That’s according to nearly two years of data from the completed Phase 3 APeX-2…

The Committee for Medicinal Products for Human Use (CHMP), an arm of the European Medicines Agency, has recommended the approval of Takhzyro (lanadelumab) for the routine prevention of hereditary angioedema (HAE) attacks in children starting at age 2. Based on a positive opinion from the CHMP, the European…

A 46-year-old man developed delayed angioedema following surgery — with his tongue swelling significantly four hours later — that likely was triggered by the use of an ACE or angiotensin-converting enzyme inhibitor to treat his high blood pressure, according to a new case report. Due to rapid evaluation by…

Pediatricians in Brazil show, in general, a low level of knowledge of hereditary angioedema (HAE), according to a recent study. Even though those who were board-certified specialists in allergy and immunology were more knowledgeable than those who weren’t, their level of knowledge was still considered unsatisfactory. “Based on the…