KalVista Pharmaceuticals‘ investigational therapy KVD900 for the treatment of hereditary angioedema (HAE) rapidly reduces the activity of plasma kallikrein, one of the drivers of HAE attacks. That promising result comes from the first-in-human Phase 1 clinical trial of KVD900, and was shared at the 11th C1 Inhibitor Deficiency…
Prophylactic (preventative) treatment with Cinryze reduced the number and severity of attacks in young children with hereditary angioedema (HAE), without significant adverse events, a Phase 3 trial shows. The study, “A Randomized Trial of human C1 inhibitor prophylaxis in children with hereditary angioedema,” was published in Pediatric…
Takhzyro (lanadelumb), an antibody already approved for routine prevention of hereditary angioedema (HAE) attacks in patients ages 12 and older, was found to safely reduce the number of monthly attacks experienced by adolescents in a Phase 3 clinical trial. The study, “Efficacy and safety of lanadelumab for prophylactic treatment…
Angiotensin-converting enzyme (ACE) activity levels can vary among different donors of fresh frozen plasma (FFP) — commonly used for the treatment of non-allergic angioedema triggered by ACE inhibitors — which may partially explain why clinical outcomes differ among these patients, a study reports. The study, “Possible donor-dependent differences in…
A recently described mutation in the plasminogen (PLG) gene has been reported in an additional family in Germany with hereditary angioedema (HAE), highlighting the importance of raising awareness among clinicians for this rare HAE-causing mutation to ensure correct disease diagnosis and treatment, scientists say. Findings were reported in…
The three prophylactic medicines currently on the market for hereditary angioedema (HAE) — the C1 esterase inhibitors Cinryze and Haegarda, and Takzyhro (lanadelumab) — all reduce the number and severity of swelling attacks in patients with type 1/2 disease, without significant adverse events, a study found. But researchers report that these…
Intestinal hereditary angioedema (HAE) should be considered as a possible cause of abdominal pain, even in patients with normal C1 inhibitor protein levels, suggests a case report study that described a woman with HAE being misdiagnosed with infectious colitis. The case study, “Wolf in the sheep’s clothing: intestinal angioedema mimicking…
Despite being more prone to developing heart disease, patients with hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) show normal blood vessel function, a study reveals. The study, “Flow mediated vasodilation assay indicates no endothelial dysfunction in hereditary angioedema patients with C1-inhibitor deficiency,” was published in Annals…
Ruconest (recombinant C1-inhibitor, rhC1-INH) and Firazyr (icatibant) are safe and effective approaches as first-line treatment for hereditary angioedema (HAE) attacks in pregnant women, a study suggests. Findings of the study, “Treatment of Hereditary Angioedema Attacks with Icatibant and Recombinant C1 Inhibitor During Pregnancy,” were published in the Journal of…
The mother of a 28-year old pregnant woman suspected her daughter had hereditary angioedema after doing an internet search while the daughter was hospitalized. The diagnosis was quickly dismissed by clinicians, who considered it extremely unlikely, but it later proved to be correct. This case report highlights the importance of…
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