Marisa Wexler, MS,  senior science writer—

Bradykinin, a key molecular player involved in swelling attacks in hereditary angioedema patients, does so by signaling through the cyclooxygenase (COX) proteins, which may be targeted with common anti-inflammatory medications such as ibuprofen and diclofenac, a study has found. By uncovering additional molecules participating in…

In Italy, people with hereditary angioedema (HAE) types 1 or 2 are not at an increased risk of premature death relative to the general population, and swelling that blocks the airway is not the main cause of death, a new study has found. The study, “Life…

Researchers have developed a new tool that measures disease activity specifically in people with hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE), which could prove useful in the medical care of patients and for assessing outcomes in clinical trials. The Hereditary Angioedema Activity Score (HAE-AS) was described in the…

Researchers developed a questionnaire, called the Angioedema Control Test (AECT), that may be helpful in monitoring disease control and patient-reported outcomes among people with recurrent angioedema. The tool is described in the journal Allergy, in the study, “Development of the Angioedema Control Test (AECT) – A Patient…

A Thai version of the Angioedema Quality of Life (AE-QoL) questionnaire is a reliable way to measure health-related quality of life in Asian people with recurrent angioedema, a new study demonstrates. The study, “Angioedema quality of life questionnaire (AE-QoL) – interpretability and sensitivity to change,” was published…

A genetic technique called allelic discrimination — which detects a specific variant of the F12 gene — might make diagnosing certain hereditary angioedema-causing mutations quicker and cheaper, a new study showed. Titled “A cost-effective algorithm for diagnosis of hereditary angioedema with normal C1 inhibitor:…

Researchers have developed a new rat model of hereditary angioedema (HAE) that more closely mimics the swelling episodes experienced by humans, which might improve studies about the mechanisms that cause the disease. The model has been described in a new paper, “Endothelial B2-receptor overexpression as an…

In a new study, researchers provide recommendations for when to consider a diagnosis of hereditary angioedema (HAE) for patients who come to the  emergency room with swelling. The study, “Development of the Hereditary Angioedema Rapid Triage (HAE-RT) Tool,” was published in The Journal of Allergy…

Haegarda, a concentrated form of C1 inhibitor (C1-INH), is safe and effectively helps to prevent hereditary angioedema attacks in the long-term, allowing patients to become free of disease symptoms, That is the finding of a Phase 3 extension study, “Long-term outcomes with subcutaneous C1-inhibitor replacement therapy for prevention…

Some mutations in the SERPING1 gene that cause hereditary angioedema (HAE) result in an abnormal form of the C1 inhibitor (C1-INH) that binds to and traps healthy C1-INH in cells, severely reducing the amount of protein available to prevent HAE attacks, a study shows. The study, “Dominant negative SERPING1…