Patricia Inácio, PhD, science writer —

Hereditary angioedema (HAE) is marked by frequent attacks and high disease burden in Canadian patients, who waited a median of 10 years for a diagnosis after the onset of their symptoms, a recent survey shows. This reality “indicates an urgent need for increased awareness and education on HAE among…

A dozen new mutations in the SERPING1 gene were identified in Slovakia as the cause of hereditary angioedema (HAE) due to C1-inhibitor deficiency or dysfunction — known as C1-INH-HAE — according to a new study based on a complex analysis. That genetic analysis also suggested that the prevalence of…

The use of vaccines against SARS-CoV-2, the virus that causes COVID-19, was not linked to an increased risk of disease worsening in people with hereditary angioedema (HAE), according to a small, single-center study from Turkey. The study also found that the viral infection was not always associated with disease worsening…

Treatment with tranexamic acid was safe and not linked to a higher risk of worse outcomes in people who developed angioedema after being on angiotensin-converting enzyme inhibitors (ACEIs), a type of blood pressure-lowering medication, a study finds. While initial findings suggested a link between tranexamic acid and greater rates…

Preventive treatment with Takhzyro (lanadelumab) reduced swelling attack frequency and improved quality of life in Japanese patients with hereditary angioedema (HAE), a small real-world study shows. The study, “Effect of lanadelumab on attack frequency and QoL in Japanese patients with hereditary angioedema: Report of five…

A 2-year-old girl with Down syndrome who was diagnosed with a rare form of hereditary angioedema (HAE) was the subject of a case report by researchers in Palestine. The child’s case was detailed in “Hereditary Angioedema With a Normal Complement…

In a 39-year-old man in France, hereditary angioedema (HAE) manifested with stroke-like symptoms, including weakness on one side of the body and difficulty speaking, despite treatment with danazol, a medication normally used to prevent HAE attacks. His symptoms eventually resolved with Takhzyro (lanadelumab), an approved therapy for…

Long-term use of attenuated androgens — male hormones used as a preventive treatment — may increase the risk for other disorders in hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE), a retrospective analysis suggests. Disorders linked with their use included high blood pressure, high cholesterol, diabetes, and benign liver tumors. “The results…

Adding a short-term regimen of C1-INH concentrate to the preventive treatment of a 63-year-old man with hereditary angioedema (HAE) enabled a successful tooth extraction without a swelling attack in his larynx, a case study reports. The tailored Orladeyo (berotralstat) prophylaxis regimen was designed to prevent an attack…

A single subcutaneous or under-the-skin injection of STAR-0215 — an experimental treatment that aims to prevent swelling attacks in people with hereditary angioedema (HAE) — led to a sustained decrease in kallikrein protein activity in healthy adults for close to three months, according to new trial data. Early…