News

An orally disintegrating tablet (ODT) formulation of sebetralstat, an investigational on-demand treatment for swelling attacks in hereditary angioedema (HAE) patients, is processed by the body in a similar way to its film-coated tablets, according to data from a Phase 1 clinical trial. Researchers are investigating these ODT tablets…

Researchers have developed a simple scoring system to help clinicians identify angioedema patients at high or low risk for intubation, a medical procedure in which a breathing tube is placed into the windpipe through the mouth or nose. Specifically, the need for a breathing tube, called endotracheal…

Women with hereditary angioedema (HAE) who have been pregnant multiple times did not experience outcomes of significant disease worsening during pregnancy, a study in Turkey found. A majority did report a greater frequency of HAE attacks during pregnancy, but this was not statistically significant, according to researchers. In patients…

The efficacy and safety of Takhzyro (lanadelumab) in preventing hereditary angioedema attacks are similar across different racial and ethnic groups, according to an analysis of data from a Phase 3 trial and its open-label extension study. However, with few patients from minorities participating in clinical trials, conclusions are…

Researchers have reported the case of a 19-year-old man whose only symptom of hereditary angioedema (HAE) was abdominal pain. His diagnosis relied on laboratory tests, which revealed normal levels, but low activity, of the C1 inhibitor protein (C1-INH) — a telltale sign of HAE type 2. The man’s case…

CSL Plasma has announced the opening of two additional plasma collection centers in California to meet the growing need for plasma-derived treatments for people with rare diseases — including hereditary angioedema (HAE). The new collection sites, hosted by the cities of Stockton and Hayward, in the central and northern parts…

Changes in the number of certain bacteria in the throat are linked to throat swelling episodes in people with hereditary angioedema (HAE), a recent study has found. Patients with recent episodes of throat swelling had significantly increased quantities of Bacteroidetes and Prevotellaceae bacteria, with increases in Bacteroidetes associated with…

The U.S. Food and Drug Administration (FDA) has agreed to review an application from Takeda to extend the approval of Takhzyro (lanadelumab) for children as young as 2 with hereditary angioedema (HAE). The application has been given priority review status and a decision from is expected in…

The Phase 2 KOMPLETE clinical trial testing the ability of oral KVD824 to prevent attacks in people with hereditary angioedema (HAE) has been terminated. The decision by the therapy’s developer, KalVista Pharmaceuticals, was based on the observation of high levels of liver enzymes, a sign of inflammation…

A booster dose of Moderna’s COVID-19 vaccine is suspected of having caused acute attacks of acquired angioedema in an 86-year-old man, a case study reported. Its scientists stressed the importance of carefully examining patients set to undergo such vaccinations and considering rarer symptoms, noting this patient reported unusual upper-limb…