News

HAE type 3 tied to more severe symptoms by doctors, patients

People with hereditary angioedema (HAE) who have normal C1-inhibitor (C1-INH) levels and activity appear to have more active disease and more severe symptoms than those with HAE type 1 or 2, a real-world study found. These patients also “experience greater impairment to their quality of life, work, and daily functioning,”…

Delayed HAE diagnosis carries substantial burden, review finds

People with hereditary angioedema (HAE) typically experience a markedly delayed diagnosis — from three to 26 years following the onset of symptoms — that results in a greater disease burden for patients, with growing HAE-related expenses from hospitalizations, medications, potentially unnecessary surgeries, and a plethora of doctor visits, according…

HAE treatment-switching process varies among patients: Study

Transitioning from other prophylactic, or preventive, treatments, to Orladeyo (berotralstat) or Takhzyro (lanadelumab) can take some time and adjustment, but helps to safely prevent swelling episodes in hereditary angioedema (HAE) patients. That’s according to a study reporting the process of such a treatment transition for four family members…

Orladeyo approved in Peru as preventive HAE treatment

The oral medication Orladeyo (berotralstat) is now approved in Peru as a prophylactic, or preventive, treatment to reduce the risk of swelling attacks in people with hereditary angioedema (HAE), ages 12 and older. The approval from Peru’s General Directorate of Medicines, Supplies and Drugs comes just months after…

Orladeyo effective for HAE with normal C1-inhibitor

Switching to Orladeyo (berotralstat) may help reduce the frequency and duration of swelling attacks in people with hereditary angioedema (HAE) who have normal levels and activity of a protein called C1-inhibitor, according to a European case series. These data add “clinically relevant evidence” to a growing body of…

Takeda joins Pentavere to advance new HAE, rare disorder treatments

A research collaboration between Pentavere Research Group and Takeda Canada has led to the creation of one of the largest cohort datasets of patients with an ultra-rare form of hereditary angioedema (HAE) where C1 inhibitor (C1-INH) protein levels are normal. The public-private partnership seeks to “revolutionize” diagnosis and care…