The prevalence of certain conditions — namely, allergies, autoimmune diseases, and asthma — is higher among people with hereditary angioedema (HAE) than in the general population, according to a new study from Canada. The data specifically showed that the proportion of HAE patients who reported having autoimmune conditions was…
A Phase 3 clinical trial testing sebetralstat as an on-demand treatment for swelling attacks in children with hereditary angioedema (HAE) has completed enrollment a year ahead of schedule. The trial’s initial target enrollment was surpassed in less than seven months, according to KalVista Pharmaceuticals, which is developing…
The symptoms of hereditary angioedema (HAE) can be very hard on adolescents, significantly affecting their health-related quality of life, particularly in regard to schooling and their social and emotional well-being, a U.S. study based on interviews with a dozen young patients reported. Those taking part, ages 12 to 17…
An oral granule formulation of Orladeyo (berotralstat) was safe and well tolerated, and able to reduce the rates of swelling attacks in children with hereditary angioedema (HAE), according to an interim analysis of an ongoing Phase 3 trial. The open-label Phase 3 APeX-P trial (NCT05453968) is assessing the…
Despite being on prophylatic, or preventive, treatment, people with hereditary angioedema (HAE) report similar struggles in managing and recovering from acute attacks to those using on-demand therapy alone, a new survey study in the U.S. has revealed. The researchers noted that anxiety levels among patients when anticipating the use…
Diet and physical activity may trigger swelling attacks in people with hereditary angioedema (HAE), according to a patient survey study conducted in Germany. About a third of patients surveyed experienced swelling attacks related to the consumption of certain foods, including fruits, vegetables, bread, or dairy products, while some…
Switching from long-term androgen treatment to Takhzyro (lanadelumab) successfully prevented swelling attacks and reduced cardiovascular risk in a man with hereditary angioedema (HAE) type 1, according to a report from Italy. The man had undergone two kidney transplants and was on immunosuppressant medications for several years. According to…
Preventing swelling attacks in children in India with hereditary angioedema (HAE) relies mostly on using tranexamic acid (TA) and attenuated androgens, or male hormones, due to the lack of accessible first-line treatment options, a single-center study shows. Neither therapy is preferred for HAE and attenuated androgens are contraindicated…
Kalvista Pharmaceuticals has submitted applications to regulatory authorities in the U.K., Switzerland, Australia, and Singapore requesting the approval of sebetralstat, an oral, on-demand treatment for hereditary angioedema (HAE) in patients ages 12 and older. The four applications were submitted through the Access Consortium framework, a coalition of…
A man who experienced recurrent episodes of tongue swelling was diagnosed with angioedema related to the use of an angiotensin-converting enzyme (ACE) inhibitor to treat high blood pressure, according to a case report. The patient’s symptoms eased after stopping treatment with the medication, lisinopril, with no recurrence of angioedema…
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