News

Pregnancy Not Linked to Worse Disease in Women With HAE: Study

Women with hereditary angioedema (HAE) who have been pregnant multiple times did not experience outcomes of significant disease worsening during pregnancy, a study in Turkey found. A majority did report a greater frequency of HAE attacks during pregnancy, but this was not statistically significant, according to researchers. In patients…

Takhyrzo Found to Be Effective HAE Treatment Across Minority Groups

The efficacy and safety of Takhzyro (lanadelumab) in preventing hereditary angioedema attacks are similar across different racial and ethnic groups, according to an analysis of data from a Phase 3 trial and its open-label extension study. However, with few patients from minorities participating in clinical trials, conclusions are…

2 New US CSL Plasma Collection Centers Open to Meet Growing Need

CSL Plasma has announced the opening of two additional plasma collection centers in California to meet the growing need for plasma-derived treatments for people with rare diseases — including hereditary angioedema (HAE). The new collection sites, hosted by the cities of Stockton and Hayward, in the central and northern parts…

Changes in Throat Microbiota Linked to HAE Swelling Episodes

Changes in the number of certain bacteria in the throat are linked to throat swelling episodes in people with hereditary angioedema (HAE), a recent study has found. Patients with recent episodes of throat swelling had significantly increased quantities of Bacteroidetes and Prevotellaceae bacteria, with increases in Bacteroidetes associated with…

KalVista Terminates KOMPLETE Trial of KVD824

The Phase 2 KOMPLETE clinical trial testing the ability of oral KVD824 to prevent attacks in people with hereditary angioedema (HAE) has been terminated. The decision by the therapy’s developer, KalVista Pharmaceuticals, was based on the observation of high levels of liver enzymes, a sign of inflammation…

Moderna COVID-19 Booster Likely Triggers Acquired Angioedema

A booster dose of Moderna’s COVID-19 vaccine is suspected of having caused acute attacks of acquired angioedema in an 86-year-old man, a case study reported. Its scientists stressed the importance of carefully examining patients set to undergo such vaccinations and considering rarer symptoms, noting this patient reported unusual upper-limb…

Japan OK’s Berinert SC Injection 2000 to Prevent HAE Attacks

Japan’s Ministry of Health, Labour and Welfare has approved Berinert S.C. Injection 2000 — a C1-inhibitor replacement therapy designed to be self-administered at home via injection under the skin twice per week — for preventing swelling attacks in people with hereditary angioedema (HAE). The therapy has been approved in…