News

People with hereditary angioedema (HAE) who switched to Orladeyo (berotralstat) from other preventive treatments generally experience a reduction in swelling attacks. That is according to real-world data presented by BioCryst Pharmaceuticals, Orladeyo’s developer, during the 2022 Annual Scientific Meeting of the American College of Allergy, Asthma…

A Japanese woman was diagnosed with a rare case of non-episodic angioedema associated with eosinophilia (NEAE), with remarkably high levels of immune eosinophil cells in her bloodstream, a recent case report describes. Swelling in her legs and feet, and associated weight gain, were successfully treated with the anti-inflammatory…

An ACE inhibitor, a common medication to control blood pressure, triggered small bowel angioedema in a 34-year-old woman, according to a case report. “Given the high prevalence of ACEi [ACE inhibitor] prescriptions, it is an important mimic to consider for other chronic intermittent intestinal diseases,” because stopping their use…

An orally disintegrating tablet (ODT) formulation of sebetralstat, an investigational on-demand treatment for swelling attacks in hereditary angioedema (HAE) patients, is processed by the body in a similar way to its film-coated tablets, according to data from a Phase 1 clinical trial. Researchers are investigating these ODT tablets…

Researchers have developed a simple scoring system to help clinicians identify angioedema patients at high or low risk for intubation, a medical procedure in which a breathing tube is placed into the windpipe through the mouth or nose. Specifically, the need for a breathing tube, called endotracheal…

Women with hereditary angioedema (HAE) who have been pregnant multiple times did not experience outcomes of significant disease worsening during pregnancy, a study in Turkey found. A majority did report a greater frequency of HAE attacks during pregnancy, but this was not statistically significant, according to researchers. In patients…

The efficacy and safety of Takhzyro (lanadelumab) in preventing hereditary angioedema attacks are similar across different racial and ethnic groups, according to an analysis of data from a Phase 3 trial and its open-label extension study. However, with few patients from minorities participating in clinical trials, conclusions are…

Researchers have reported the case of a 19-year-old man whose only symptom of hereditary angioedema (HAE) was abdominal pain. His diagnosis relied on laboratory tests, which revealed normal levels, but low activity, of the C1 inhibitor protein (C1-INH) — a telltale sign of HAE type 2. The man’s case…

CSL Plasma has announced the opening of two additional plasma collection centers in California to meet the growing need for plasma-derived treatments for people with rare diseases — including hereditary angioedema (HAE). The new collection sites, hosted by the cities of Stockton and Hayward, in the central and northern parts…

Changes in the number of certain bacteria in the throat are linked to throat swelling episodes in people with hereditary angioedema (HAE), a recent study has found. Patients with recent episodes of throat swelling had significantly increased quantities of Bacteroidetes and Prevotellaceae bacteria, with increases in Bacteroidetes associated with…