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A new international guideline recommends Ekterly (sebetralstat), Kalvista Pharmaceuticals’ approved oral therapy for hereditary angioedema (HAE), as a first-line option for timely, on-demand resolution of HAE swelling attacks in children ages 12 and older. The committee behind these new pediatric guidelines stated in a study recommendation that adolescents with…

Caring for children and adults with hereditary angioedema (HAE) places heavy demands on caregivers and can significantly affect their emotional well-being, work, and personal lives, according to a multinational survey conducted in Europe and South America. “Results of this caregiver survey revealed that the caregiver role in HAE is…

For people with hereditary angioedema (HAE), regardless of a person’s racial or ethnic background, living with this chronic disease can take a toll on emotional well-being and cause difficulty engaging in day-to-day activities, a new study found. The research specifically examined non-white patients, addressing a gap in earlier studies…

Biocryst Pharmaceuticals will present new clinical trial and real-world data on its treatments for hereditary angioedema (HAE) at this year’s American Academy of Allergy, Asthma & Immunology (AAAAI) annual meeting, the company announced. The data include six abstracts reporting updated findings on Orladeyo (berotralstat), an approved oral…

Using Takhzyro (lanadelumab) cut monthly swelling attacks by about 80% in newly treated people with hereditary angioedema (HAE) in Canada, and helped maintain low attack rates among those already on the therapy. Further, the injection treatment was generally well tolerated, with no serious side effects reported. These findings come…

People with type 3 hereditary angioedema (HAE) may report more frequent swelling attacks than people with HAE types 1 or 2, according to a new survey study. The findings also suggest people with HAE type 3 may be more likely to experience potentially life-threatening throat swelling and to report…

Adults with hereditary angioedema (HAE) experience physical stress responses similar to those with other chronic conditions, such as the autoimmune condition immune thrombocytopenia (ITP), in which stress is usually not involved in disease flare-ups. A new study found that when faced with stressful tasks, HAE patients showed heart…

Biocryst Pharmaceuticals has acquired Astria Therapeutics, and with it navenibart, an investigational treatment to prevent swelling attacks in people with hereditary angioedema (HAE). Navenibart is being tested in the Phase 3 ALPHA-ORBIT trial (NCT06842823), which is recruiting patients, ages 12 and older with HAE type…

A 54-year-old man with sudden, unexplained abdominal pain was diagnosed with intestinal angioedema — marked by swelling of the gastrointestinal tract — linked to the use of the common blood pressure drug lisinopril, according to a case report. His symptoms resolved quickly after stopping treatment with the medication,…

The case of a new mother who developed severe acute allergic angioedema triggered by a common antibiotic was described by researchers in India in a new report, with the team seeking to stress the importance of early and “aggressive” treatment of reactions to even routinely used drugs. The woman,…