News

Researchers have reported the case of a 19-year-old man whose only symptom of hereditary angioedema (HAE) was abdominal pain. His diagnosis relied on laboratory tests, which revealed normal levels, but low activity, of the C1 inhibitor protein (C1-INH) — a telltale sign of HAE type 2. The man’s case…

CSL Plasma has announced the opening of two additional plasma collection centers in California to meet the growing need for plasma-derived treatments for people with rare diseases — including hereditary angioedema (HAE). The new collection sites, hosted by the cities of Stockton and Hayward, in the central and northern parts…

Changes in the number of certain bacteria in the throat are linked to throat swelling episodes in people with hereditary angioedema (HAE), a recent study has found. Patients with recent episodes of throat swelling had significantly increased quantities of Bacteroidetes and Prevotellaceae bacteria, with increases in Bacteroidetes associated with…

The U.S. Food and Drug Administration (FDA) has agreed to review an application from Takeda to extend the approval of Takhzyro (lanadelumab) for children as young as 2 with hereditary angioedema (HAE). The application has been given priority review status and a decision from is expected in…

The Phase 2 KOMPLETE clinical trial testing the ability of oral KVD824 to prevent attacks in people with hereditary angioedema (HAE) has been terminated. The decision by the therapy’s developer, KalVista Pharmaceuticals, was based on the observation of high levels of liver enzymes, a sign of inflammation…

A booster dose of Moderna’s COVID-19 vaccine is suspected of having caused acute attacks of acquired angioedema in an 86-year-old man, a case study reported. Its scientists stressed the importance of carefully examining patients set to undergo such vaccinations and considering rarer symptoms, noting this patient reported unusual upper-limb…

Japan’s Ministry of Health, Labour and Welfare has approved Berinert S.C. Injection 2000 — a C1-inhibitor replacement therapy designed to be self-administered at home via injection under the skin twice per week — for preventing swelling attacks in people with hereditary angioedema (HAE). The therapy has been approved in…

A splenic marginal zone lymphoma (SMZL) — a type of non-Hodgkin’s lymphoma that involves the spleen, bone marrow, and blood — might have triggered acquired angioedema in a man in his 60s, a case study reported. “The occurrence of [non-Hodgkin’s] lymphoma in association with [acquired…

Half the patients with hereditary angioedema (HAE) treated with Takhzyro (lanadelumab) for at least a year prolonged their dosing interval and used significantly less on-demand treatments, a real-world study found. Study findings were detailed in a clinical letter titled, “Real World treatment patterns of hereditary angioedema with…

A single infusion of the investigational gene therapy NTLA-2002 was well tolerated at two different doses and reduced the number of swelling attacks in people with hereditary angioedema (HAE) by more than 90%, according to interim results from the Phase 1 portion of a Phase 1/2 trial. The…