News

A new diagnostic tool has been identified for people with hereditary angiodema (HAE) and normal C1 inhibitor activity, potentially establishing the first method that doctors can use to properly diagnose this genetic condition, a study suggests. The study, “sgp120 and the contact system in hereditary…

Researchers have developed a new tool that measures disease activity specifically in people with hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE), which could prove useful in the medical care of patients and for assessing outcomes in clinical trials. The Hereditary Angioedema Activity Score (HAE-AS) was described in the…

Use of ACE inhibitors to treat high blood pressure can sometimes cause swelling (angioedema) episodes, but the prevalence of this potentially life-threatening side effect is not well-known because it is rarely reported, a Danish study into a “drug reaction” database found. The study, “ACE-Inhibitor Related Angioedema Is…

Results of the Phase 2 clinical trial testing KalVista Pharmaceuticals‘ oral investigational therapy KVD900 as an on-demand treatment for hereditary angioedema (HAE) attacks will be announced by August. The company also announced it has selected KVD824 as an oral preventive therapy for HAE. A Phase 2…

Researchers have identified risk factors that may predispose children to more severe initial angioedema attacks — factors such as male gender, preschool age, presence of fever or hives, and a history of allergies. Epinephrine treatment and receiving care in a pediatric observation unit, on the other hand, were factors that…

Researchers developed a questionnaire, called the Angioedema Control Test (AECT), that may be helpful in monitoring disease control and patient-reported outcomes among people with recurrent angioedema. The tool is described in the journal Allergy, in the study, “Development of the Angioedema Control Test (AECT) – A Patient…

The lack of control of a key enzyme associated with the overproduction of bradykinin seems to be the common root cause of all forms of hereditary angioedema with normal C1-inhibitor activity, a study reports. The study, “Impaired control of the contact system in hereditary angioedema with…

A Thai version of the Angioedema Quality of Life (AE-QoL) questionnaire is a reliable way to measure health-related quality of life in Asian people with recurrent angioedema, a new study demonstrates. The study, “Angioedema quality of life questionnaire (AE-QoL) – interpretability and sensitivity to change,” was published…

Angioedema News brought you daily coverage of important discoveries, treatment developments, clinical trials, and other important events dealing with angioedema throughout 2019. As a reminder of what mattered most to our readers in 2019, here are the 10 most-read articles of last year, with a brief description of…

KVD001 safely protects people with diabetic macular edema from losing their vision, according to a Phase 2 trial conducted by the treatment’s developer, KalVista Pharmaceuticals. DME is a form of angioedema that is caused by the leaking of blood vessels which lead to fluid accumulating in the…