The U.S. Food and Drug Administration (FDA) has accepted Biocryst Pharmaceuticals’ application to approve an oral granule formulation of Orladeyo (berotralstat) for children with hereditary angioedema (HAE) as young as 2. The FDA granted the application priority review, which shortens the process from the standard 10 months…
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To mark Hereditary Angioedema (HAE) Awareness Day this year, the advocacy group HAE International is smiling: The theme for the events of Friday, May 16, is “hae day,” with punctuation marks creating a smiley face. An annual worldwide event, HAE Awareness Day aims to familiarize people with…
Biocryst Pharmaceuticals has submitted an application asking the U.S. Food and Drug Administration (FDA) to extend the approval of Orladeyo (berotralstat) to children with hereditary angioedema (HAE) as young as 2 years. The application specifically seeks the approval of an oral granule formulation of the therapy for…
The use of the antibody navenibart, being developed by Astria Therapeutics to prevent swelling episodes in hereditary angioedema (HAE), resulted in the sustained inhibition of kallikrein — an enzyme that’s overactive in HAE patients — in healthy volunteers in a clinical trial, supporting its…
More than 90% of people with hereditary angioedema (HAE) are interested in trying new prophylactic (preventive) treatments, according to a recent poll. The survey also highlighted disconnections between patients and clinicians, and their impressions of how well the disease is being managed. The poll surveyed 150 adults living…
Most allergist-immunologists who treat people with hereditary angioedema (HAE) think genetic testing may be useful in diagnosing irregular cases, but many say they require more education to feel confident with the specifics of testing, a study reports. “The study found that [health care providers] consider genetic testing during a…
Andembry (garadacimab), a first-in-class treatment to prevent swelling attacks in people with hereditary angioedema (HAE), ages 12 and older, is now available in Japan. The treatment was approved by Japan’s Ministry of Health, Labour and Welfare in February, Andembry is the first prophylactic (preventive) therapy in Japan that…
A man in his 60s who developed severe angioedema after the use of an ACE, or angiotensin-converting enzyme, inhibitor to treat high blood pressure required several emergency interventions before making a full recovery, according to a case study from France. Swelling in the man’s throat obstructed his breathing, ultimately…
A simple diagnostic score may help distinguish between two types of angioedema — mast cell-mediated angioedema and drug-induced nonallergic angioedema — in people taking angiotensin-converting enzyme (ACE) inhibitors, researchers said. They described the scoring system in the study, “Angiotensin-converting enzyme inhibitor-induced angioedema: Proposal for a diagnostic…
People from underrepresented racial and ethnic groups who have hereditary angioedema (HAE) continue facing barriers to diagnosis and effective care, according to a recent study. These patients reported having trouble getting adequate care before their diagnosis, and though most were satisfied with the treatment they received afterward, many…
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